In CFS/ME, where energy delivery is impaired, one may expect detoxification also to be impaired. Strictly speaking it is not a hole but a valve which should snap shut and stick shut at the moment of birth. Digamos que la Acetil L-Carnitina lleva hecha una parte del trabajo, por lo que actúa más rápidamente. Worse still, these foods provide a very short-term, addictive buzz of energy. You must pace better! Effect of coenzyme q10 on myopathic symptoms in patients treated with statins. 249 Kč . It also binds to toxic metals and increases their excretion in urine. So it is with recovering from CFS/ME and this is illustrated by modelling the situation with catastrophe theory – see Catastrophe theory: why we get into and how we get out of CFS. Remember, shortness of breath may also result from heart failure, respiratory distress and anaemia, and these symptoms need investigating as a separate issue. There is no official Daily Value recommendation, but Dr. Weil suggests at least 90 to 120 mg of supplemental CoQ10 for any adult taking statin medications and for those with a family history of heart problems, or who is at increased risk for cardiovascular disease. Reduce demands – pace as well as possible. The richest natural sources of dietary coenzyme Q10 are meat, poultry and fish, but vegetarian options, such as beans, nuts, some vegetables, eggs and dairy products, are also helpful for increasing your intake. According to Dr Sarah Myhill (11) the synthesis of this molecule can be inhibited by chronic illness and toxins. There is the added bonus that dealing with them can convert them into virtuous circles. This is because 40 per cent of resting energy simply powers the ion pumps for sodium/potassium (Na/K) and calcium/magnesium (Ca/Mg) across cell membranes (an essential ongoing process for life). Have great week. So what are those common vicious cycles? J Am Coll Cardiol 2007;49:2231-7. Solo tomo 100mg y quiero consultar al reumatólogo si tomar mas o seguir un tiempo con esa cantidad. There is also a new form of CoQ10 that is referred to as Pyrroloquinoline quinone (PQQ) that some claim to be more effective. Possibly, for example, polymyalgia rheumatica is muscles becoming allergic to gut microbes. The solution is the PK diet. Typically, this just lasts a few seconds. Objective To determine the effects of coenzyme Q10 (CoQ10) for reduction in the severity, frequency of migraine attacks and duration of headache in adult patients with migraine. Having low levels. Over to Craig who has walked and is walking the path……. (Do not disturb my circles! Caso G, Kelly P, McNurlan MA, et al. See. Dr Julie Iodine – Iodine displaces toxic ‘halides’, such as fluoride and bromide. Ketosis is an often misunderstood subject. Worse still, the symptoms these foods create mean that those with CFS/ME may turn to other addictions to relieve those symptoms – to caffeine, nicotine and possibly others. Eating protein – this is broken down into amino acids (such as methionine) and shortchain polypeptides (such as glutathione) which are important co-factors for excreting toxins. Then the allergy is switched on at that time and the pain which follows the muscle damage, and which persists long term is mis-attributed to damage, when actually it is sensitisation. Coenzyme Q10 supplements can boost fertility in both men and women. What makes this journey worse are vicious cycles. Coenzyme Q10 is an energy molecule within our cells. But if the heart is weak, as it is in CFS/ME patients because of poor mitochondrial function, then the pressure difference is lost and the valve may blow open. This goes unrecognised by cardiologists who call it “atypical cardiac pain”. This sets up a vicious cycle here because these are the very foods which result in metabolic syndrome, fermenting gut, allergy and micronutrient deficiencies all of which deplete energy. por cacoya » 28 Jun 2011, 17:57, Mensaje Additional micronutrients to improve antioxidant status, viz: Superoxide dismutase – copper 1 milligram, manganese 3 milligrams and zinc 30 milligrams for 4 months to correct a deficiency. After reading about statins and coenzyme Q10, a reader commented that she knew of at least sixteen women in their 40s who successfully became pregnant while taking coenzyme Q10 supplements. 'Quote re circles within circles' As Black Elk [Nicholas Black Elk [Hehaka Sapa] (c. December 1863 – 17 August or 19 August 1950 [sources differ]), famous Wichasha Wakan (Medicine Man or Holy Man) and Heyoka of the Oglala Lakota (Sioux)] said: “The Universe is circles within circles, and everything is one circle, and all the circles are connected to each other.”. Diet, Detox and Die-off Reactions - expect to get worse. Fermenting gut --> produces hydrogen sulphide --> hydrogen sulphide helps the absorption of toxic metals --> these toxic metals accumulate where the liver cannot detox them (eg brain) --> this accumulation is made worse if the sufferer is low in friendly trace elements because the body will grab ‘look-alike’ toxic metals to use in the place of those friendly trace elements --> the synthesis of super-oxide dismutase and glutathione peroxidase is less efficient --> the body has a poorer detox system --> toxic metals accumulate more quickly --> …. See this checklist and be as rigorous as you can on Stage 2 -, Essentially this means doing as much of Groundhog BASIC as possible – see, Then as you feel better you can gradually add in new interventions, BUT the best way – easier said than done – is to never get into this situation in the first place. This dosage is also appropriate for otherwise healthy men and women as a preventive measure and to help maintain a healthy cardiovascular system. It will take about 4 weeks for levels to plateau. Energy is like money- - it is great fun spending it but jolly hard work earning it! Much of this energy is for detoxification. Please accept my deepest apologies if any of these words offend or appear to trivialise, or don't seem to 'fit' your situation. The release of energy from ATP is magnesium dependent, as is the synthesis of ATP from ADP. Hyperventilation changes the acidity of the blood (it becomes more alkali) so that oxygen sticks more avidly to haemoglobin so worsening oxygen delivery. These tools are readily accessible to all, but some do require a determination and strength of will that is difficult to muster when one is feeling so very ill. All I can say is that I have faced many of these vicious circles and I have found that breaking them, however hard, is its own reward through improved functionality and reduced symptom load. This can happen suddenly and I suspect this explains why some CFS patients can very quickly deteriorate in a way not commensurate with increased activity. CoQ10 is a well-known supplement and can sometimes also go by the following names: Coenzyme Q10, CQ10, ubidecarenone, and ubiquinone. [Historical Note - A sailing vessel is “in irons” when she is trapped in the “No Go Zone”, unable to bear away and begin sailing. Remember that. However this progression means, to use a nautical analogy, you are sailing close to the wind. Poor energy delivery due to poor mitochondrial function --> poor detoxification --> more toxins remain present in the body’s systems --> worsening energy delivery mechanisms --> …. He (and normally it is a he too!) Initially any stretch will cause it; then, as things settle down, only a sudden stretch will do that. 5 thoughts on “Dr. Consider prescription or other medications or supplements – eg Valerian, Herbal Teas, Rescue Remedy, Diazepam… However, do take care here as you may hit another ‘vicious circle within a vicious circle’ here because some prescription medication inhibit mitochondrial function directly, thereby reducing your energy delivery mechanism and possibly making you less able to deal with situations that you previously were able to deal with. Though still controversial, some preliminary evidence suggests that CoQ10 may help to prevent or treat the adverse effects, such as muscle pains and liver problems, of taking statin-type cholesterol drugs. Consider psychological interventions (counselling etc) but choose your counsellor well and make sure that they understand that CFS/ME is a physical illness and that psychological interventions do not cure CFS/ME but rather may help with dealing with the awful consequences. Some of these toxins are external to the body, whereas others are caused by the fermenting gut, itself a result of an incorrect diet (high carbs and sugar, etc). Further good news is that many solutions ‘multi-task’ in that they break more than one of these vicious circles. The sufferer protects him/herself from the pain by moving slowly. Allergic muscles causing spasm --> spasm causing build of toxic metabolites --> this build up of toxic metabolites causes more pain --> the muscles react to this pain with further spasm --> …. The role of coenzyme Q10 in statin-associated myopathy: a systematic review. That enzyme, you don’t have to remember that, but that enzyme produces two products, 1) cholesterol, and 2) coenzyme Q10. Dr. ... Coenzyme Q10, etc.). Metabolic syndrome is a problem because CFS/ME sufferers do not have the energy to cook. For example, consider the Toxins Vicious Circle, which becomes Virtuous as below: Good energy delivery due to good mitochondrial function --> good detoxification --> fewer toxins remain present in the body’s systems --> improving energy delivery mechanisms --> …. Our bodies make CoQ10, though less as we age, and store it in our mitochondria. por elipoarch » 28 Jun 2011, 17:44, Mensaje This bio-accumulation is worse when the body is deficient in friendly trace elements – if it cannot, for example, access zinc for enzyme systems then the body will grab something which ‘looks’ similar, such as arsenic or nickel. no me lo puedo creer.. llevo muchos años con dolor de piernas y después de dos- tres semanas tomando Q10 se me ha ido un 80% de dolor.. años tomando medicamentos para la circulación, ibuprofenos para poder dormir unas horas, duchas frías, etc, Estoy emocionada con este hallazgo. There is a general belief that a high fat diet results in high cholesterol, which results in arterial and heart disease. Historical Note - According to Valerius Maximus, the phrase was uttered by Archimedes. Myhill asserts that Co-Q10 works best when used with magnesium, D-Ribose, acetyl L … As Dr. Greger says, the best way to maintain your level of CoQ10 may be to eat more plant-based, chlorophyll-rich diets. The good news is that we have at our disposal the tools needed to break these vicious circles and often we can reverse them into virtuous circles. However, I know of many great therapists and of a great many sufferers who have been helped in this way. So, to be blunt to the point of rudeness, you have to “get your shit together” and hold it there even as you worsen. It’s rare to have side effects because it’s a natural substance. After that, one of the soldiers killed Archimedes, despite the order of Marcus Claudius Marcellus. However, the interventions often multi-task and are available to all. Taking Vitamin C - increases excretion of toxic metals in urine. This does not matter so long as the higher pressure in the left atrium compared to the right atrium holds the flap shut. [See also this Blog - CFS/ME – Vicious circles and multitasking]. In this way, we can see how the fermenting gut ‘helps’ the absorption of toxic inorganic metals. Coenzyme Q10 is a compound that helps your cells make energy. There are many vicious circles in CFS/ME and these represent a further block to recovery, or worse still, contribute to a decline in functionality and an increase in symptom load. Every cell in your body has a power plant. My doctor thinks I have CFS. Once again, please accept my deepest apologies if I have seemed to trivialise what can be a truly awful situation. Coenzyme Q10 as ubiquinol – 100 milligrams daily; Vitamin B12 is an excellent antioxidant - 1 milligram (1000 micrograms) by daily injection. Sarah Myhill Limited :: Registered in England and Wales :: Registration No. This is a hole in the heart between the left and right atria (which normally closes as a flap at birth); this means that blood bypasses the lungs and does not pick up oxygen as it should. This paper has been an exercise in collation. If it cannot access selenium then it will grab something which ‘looks’ similar, such as lead or mercury. This is a vast topic and I have included only a brief summary here, for completeness. If you have never tried d-ribose yet, it is well worth a try. Further pain develops because the blood circulation through the muscles is disturbed and there is the build-up of toxic metabolites, in particular lactic acid and lactic acid causes pain. Learn to identify them and use this knowledge to make you even more determined. Menopause workshops. The business of dealing with toxins requires energy – and a lot of it. Poor energy delivery as a result of poor mitochondrial function --> insufficient energy to drive the ion pumps for sodium/ potassium (Na/K) and calcium/magnesium (Ca/Mg) across cell membranes --> magnesium cannot be drawn into cells for oxidative phosphorylation to work --> energy delivery further impaired because the release of energy from ATP is magnesium dependent, as is the synthesis of ATP from ADP --> …. Try to do what you can and pick the easy and cheap (er) things first. We can get CoQ10 through food sources or dietary supplements. See. CFS/ME – Vicious circles and multitasking, Sarah’s book ‘Diagnosis and Treatment of CFS and ME – it’s mitochondria not hypochondria!’, The Paleo Ketogenic Diet - this is a diet which we all should follow, Our book 'The PK Cookbook - Go Paleo-ketogenic and get the best of both worlds', Healing the Emotional Hole in the Energy Bucket, Vitamin C - learn to use this vital tool well – the key is getting the dose right, Nutritional Supplements - what everybody should be taking all the time even if nothing is wrong, Sales at Dr Myhill Transdermal Magnesium Spray, http://drmyhill.co.uk/drmyhill/index.php?title=Vicious_circles_in_CFS/ME&oldid=19967, Women's health, fertility and healthy babies, Feed mitochondria their preferred fuel which are ketones ie the PK diet - see, Give mitochondria the raw materials to function with the mitochondrial bolt on package, Coenzyme Q10 as ubiquinol – 200 milligrams, Vitamin B3 as niacinamide – 500-1500 milligrams – slow release, D-ribose – up to 15 grams (but this must be part of the carb count of the PK diet), Vitamin B12 – 5 milligrams sublingually or ideally B12 by injection, Magnesium – ½ ml 50% magnesium sulphate by injection, ideally, together with 300mg orally and vitamin D 10,000iu daily to enhance absoprtion, Identify blockages – the common ones are products of the fermenting gut, pesticides and VOCs (can be got rid of with heating regimes - see, Look at the control mechanisms – thyroid accelerator pedal and the adrenal gearbox see, Improve the mitochondria as above - mitochondrial bolt on package, Hyperventilation is adrenalin driven. 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